Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine

Modified Live Virus and Killed Virus

CattleMaster 4+VL5 is for vaccination of healthy cattle, including pregnant cows, as an aid in preventing infectious bovine rhinotracheitis caused by infectious bovine rhinotracheitis (IBR) virus, bovine viral diarrhea caused by bovine viral diarrhea (BVD) Type 1 virus, disease caused by parainfluenza3 (PI3) virus and bovine respiratory syncytial virus (BRSV), campylobacteriosis (vibriosis) caused by Campylobacter fetus, and leptospirosis caused by Leptospira canicola, L. grippotyphosa, L. hardjo, L. icterohaemorrhagiae, and L. pomona.

CattleMaster 4+VL5 is a freeze-dried preparation of chemically altered strains of IBR and PI3 viruses and modified live BRSV plus a liquid, adjuvanted preparation of inactivated cytopathic and noncytopathic BVD Type 1 virus strains, C. fetus, and cultures of the 5 Leptospira serovars identified above. The liquid component is used to rehydrate the freeze-dried component. Viral antigens are propagated on an established cell line. This product is adjuvanted with aluminum hydroxide to enhance immune response.

• Helps provide protection against four major viral respiratory diseases of cattle, plus protection against campylobacteriosis (vibriosis) and five common causes of leptospirosis.
• Contains chemically altered, temperature-sensitive IBR and PI3 strains that do not grow outside the upper respiratory tract and are incapable of systemic replication or fetal infection.
• The non-shedding, non-immunosuppressive and non-abortigenic viral agents used in CattleMaster vaccines are safe for use in any cow, any calf, any time.
• Annual revaccination with a single dose is recommended.

1. General Directions: Vaccination of healthy cattle, including pregnant cows, is recommended. Aseptically rehydrate the freeze-dried vaccine with the liquid component provided, shake well, and administer 5 mL intramuscularly. In accordance with Beef Quality Assurance guidelines, this product should be administered in the muscular region of the neck.
2. Primary Vaccination: Healthy cattle should receive 2 doses administered 2-4 weeks apart. To avoid possible maternal antibody interference with active immunization, calves vaccinated before the age of 6 months should be revaccinated after 6 months of age.
3. Revaccination: Annual revaccination with a single dose is recommended.
4. Good animal husbandry and herd health management practices should be employed.

PRECAUTIONS:

Store at 2°-7°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.

Use entire contents when first opened.

Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.

Burn containers and all unused contents.

Do not vaccinate within 21 days before slaughter.

Contains gentamicin as preservative.

Occasional hypersensitivity reactions may occur up to 18 hours postvaccination. Owners should be advised to observe animals during this period. While this event appears to be rare overall, dairy cattle maybe affected more frequently than other cattle. Animals affected may display excessive salivation, incoordination, and/or dyspnea. Animals displaying such signs should be treated immediately with epinephrine or equivalent. In nonresponsive animals, other modes of treatment should be considered.

As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are persistently infected with BVD virus or incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.

CONSULT YOUR LARGE ANIMAL VETERINARIAN

References:

1. Jones C: Alphaherpesvirus latency: Its role in disease and survival of the virus in nature. Adv in Vir Res 51:81-133, 1999.

Technical inquiries should be directed to Zoetis Inc. Veterinary Services, (888) 963-8471 (USA), (800) 461-0917 (Canada).

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